Right-left and sex dependent differences of hippocampus and amygdala sizes and their relation to the clinical symptoms of schizophrenia: a comparative brain segmentation study

Amani Abdelrazag Elfaki, Tahir Osman Ali, Amira Mohamed Osman, Meltem Acar Gudek, Murat Golpinar, Ibrahim Erkan, Bunyamin Sahin


Objectives: Recently, scientists try to establish suggestions about the role of hippocampus and amygdala in schizophrenia. In the current study, the volumes of the hippocampus and amygdala have been examined depending on the right and left sides and sex in patients with schizophrenia and controls. We also evaluated the relation between the quantitative data and their relation to the clinical symptoms of patients.

Methods: 82 controls (47 male, 35 female) and 54 schizophrenic patients (28 male, 26 female) participated in the study. Structural magnetic resonance images were used to determine hippocampal and amygdala volumes that were automatically obtained using automatic brain segmentation software.

Results: Mean volumes of the right hippocampus in male/ female controls and patients were (4.32±0.36 / 4.06±0.29 cm3) and (4.00 ±0.47 / 3.59±0.38 cm3). Mean volumes of the left hippocampus in male/ female controls and patients were (4.13±0.45 / 3.94±0.38 cm3) and (3.70±0.76 / 3.61±0.38 cm3). Mean volumes of the right amygdala in male/ female controls and patients were (1.57±0.21 / 1.41±0.19 cm3) and (1.54±0.21 / 1.23±0.15 cm3). Mean volumes of the left amygdala in male/ female controls and patients were (1.47±0.18 / 1.35 ±0.18 cm3) and (1.36±0.28 / 1.15 ±0.14 cm3).

Conclusions: The present study demonstrates that abnormal volumes of the hippocampus and amygdala were evident in patients with schizophrenia in comparison with the controls. Female patients have hippocampal volume reduction on the right side, In addition to bilateral volume reduction of amygdala. In this study, patients with schizophrenia displayed marked thought disorder and social withdrawal.

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